Mariangeli Moneró-Paredes
Gurabo
Summary
- PhD in Pharmacology with experience in process validation, manufacturing investigations, and cGMP compliance within regulated industries.
- Proven track record in technical writing, process optimization, and cross-functional collaboration to drive continuous improvement.
- Excellent oral and written communication skills in both English and Spanish, able to convey complex scientific information and lead global/local presentations.
- Skilled in data analysis (JMP, Prism 9, MS Excel), and proficient at interpreting findings to implement corrective and preventive actions.
- Demonstrated leadership in project management, training, and mentoring junior team members.
Overview
11
11
years of professional experience
Work History
Senior Scientist TS/MS
Lilly del Caribe
02.2023 - Current
- Provided technical support on process validation of dry products and introduction of new suppliers for raw material.
- Conducted scientific analysis and prepared technical reports as molecule steward.
- Led cross-functional manufacturing investigations to address deviations and complaints, proposing and implementing corrective and preventive actions (CAPA) for robust compliance and continuous improvement.
- Delivered technical presentations at both, local and global meetings, effectively communicating scientific data.
- Led the creation and implementation of change controls in an effective and timely manner.
- Collaborated with multiple functional areas to identify best practices for improvement, ensuring compliance with cGMPs.
- Identified changes in process variability and implemented actions accordingly.
Graduate Research Scientist
Department of Pharmacology and Toxicology, University of Puerto Rico-Medical Sciences Campus
08.2018 - 12.2022
- Designed and performed experimental studies such as genotyping, western blot analysis, and enzyme activity for the characterization and validation of PON1 protein in plasma.
- Managed and executed a collaborative project in the Cardiovascular Center of Puerto Rico and the Caribbean that resulted in the validation of a clinical decision support tool based on a pharmacogenomic-guided algorithm to tailor antiplatelet treatment to Caribbean Hispanics.
- Communicated complex scientific findings in a clear manner that resulted in 6 poster presentations and 4 publications.
- Obtained teaching experience by training personnel and 8 students (BS, PharmD, and PhD) on the topic of pharmacogenomic research.
- Engaged and established relationships with medical doctors, scientists, and patients.
- Analyzed data using statistical tools.
Graduate Research Scientist
Department of Environmental Health, University of Puerto Rico-Medical Sciences Campus
08.2014 - 05.2016
- Prepared the standard operating procedure (SOP) for the processing and analysis by HPLC of the urinary metabolite 1-hydroxypyrene.
- Optimized the detection of the urinary metabolite 1-hydroxypyrene by Solid Phase Extraction and HPLC.
Education
Ph.D. - Pharmacology
University of Puerto Rico
12.2022
M.S. - Environmental Health
University of Puerto Rico
12.2016
B.S. - General Biology
University of Puerto Rico
12.2014
Skills
- Technical writing and documentation
- High-resolution liquid chromatography (HPLC)
- Solid phase extraction
- Western blot analysis
- Genotyping: TaqMan assay and microarray
- Enzyme activity assay
- PBMC isolation
- P2Y12 assay using VerifyNow
- Data analysis: JMP, Prism 9, Plink, MS Excel
- Data management: Darwin, CIMS system, PMX, REDCap system
- Reports and presentations: MS Word, PowerPoint, Quality Docs
- Deviation management: TrackWise system
Publications
- Implementing a pharmacogenomic-driven algorithm to guide antiplatelet therapy among Caribbean Hispanics: a non-randomised clinical trial., Nuñez-Medina HJ, Monero M, Torres LM, Leal E, Gonzalez-Sepulveda L, Mayor ÁM, Renta JY, González-García ER, González A, Melin K, Scott SA, Ruaño G, Hernandez-Suarez DF, Duconge J., BMJ Open, 09/05/24, 14, 9, e084119, 10.1136/bmjopen-2024-084119, 39242160, PMC11381646
- Non-Random Enrichment of Single-Nucleotide Polymorphisms Associated with Clopidogrel Resistance within Risk Loci Linked to the Severity of Underlying Cardiovascular Diseases: The Role of Admixture., Monero-Paredes M, Feliu-Maldonado R, Carrasquillo-Carrion K, Gonzalez P, Rogozin IB, Roche-Lima A, Duconge J., Genes (Basel), 09/17/23, 14, 9, 1813, 10.3390/genes14091813, 37761953, PMC10531115
- Pharmacogenomic polygenic risk score for clopidogrel responsiveness among Caribbean Hispanics: A candidate gene approach., Duconge J, Santiago E, Hernadez-Suarez DF, Monero M, et al., Clinical and Translational Science, 2021, 14, 6, 2254-2266
- Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation., Claudio-Campos K., Moneró-Paredes M., Hernández E., Renta,J. and Duconge J., Pharmacogenomics, 2019, 20, 12, 891-902
Awards
- NIGMS-RISE Program Fellowship, 2020-2022
- Scientist Mentoring & Diversity Program for Biotechnology (SMDP Biotech) Scholar, 2020
- Student Leader Award, Associate Deanship of Biomedical Sciences, UPR-Medical Sciences Campus, 2020, 2021
- Research Excellence Award, Associate Deanship of Biomedical Sciences, UPR-Medical Sciences Campus, 2020, 2021
- Academic Excellence Award, Associate Deanship of Biomedical Sciences, UPR-Medical Sciences Campus, 2019, 2020
- Academic Excellence & Leadership, School of Public Health, UPR-Medical Sciences Campus, 2016
Languages
- Spanish, Native
- English, Full professional proficiency
Timeline
Senior Scientist TS/MS
Lilly del Caribe
02.2023 - Current
Graduate Research Scientist
Department of Pharmacology and Toxicology, University of Puerto Rico-Medical Sciences Campus
08.2018 - 12.2022
Graduate Research Scientist
Department of Environmental Health, University of Puerto Rico-Medical Sciences Campus
08.2014 - 05.2016
Ph.D. - Pharmacology
University of Puerto Rico
M.S. - Environmental Health
University of Puerto Rico
B.S. - General Biology
University of Puerto Rico
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